Treatment Modalities for Aromatase Inhibitor-Associated Musculoskeleta JPR

I was introduced to fitness in high school and after watching Generation Iron movies. I have competed multiple times, even winning a junior title in classic physique. I have a bachelor’s in criminal justice and business obtained through Alvernia University. When I am not focused on work or training, I enjoy watching films or reading about anything and everything.

First Things First – What Is an Aromatase Inhibitor?

A reduction in estrogen levels can lead to changes in sexual desire and function. Estrogen plays a role in modulating libido and erectile function, even in men. Aromatase inhibitors can also have significant effects on sexual health and reproductive function in men. These medications influence hormone levels that are critical for sexual desire, function, and fertility. Dimitrov NV, Colucci P, Nagpal S. Some aspects of the endocrine profile and management of hormone-dependent male breast cancer.

Changes in gonadal hormones

• For example, the use of vaginal lubricants, moisturizers, and vaginal massage with coconut oil are some examples of treatments that may benefit women who experience vaginal dryness or pain (Lee et al., 2011).
• In one study that was conducted in premenopausal and postmenopausal women, it was reported that the intake of dietary fat at a high level, mostly saturated fat directly affected the level of estrogen in the blood (17).
• Polyphenols are found in plants and seeds and are essentially an antioxidant that can bring us many health benefits.

It is given by injection into the buttocks every 2 weeks for a month, then monthly. If you’re concerned about your estrogen level or experiencing symptoms that may indicate higher than usual estrogen levels, it might be worth meeting with your doctor. They can carefully monitor your hormone levels with blood tests, and discuss hormone therapy options with you. Aromatase inhibitors (AI) have been used in the treatment of idiopathic short stature (ISS), constitutional delay of puberty (CDP) and precocious puberty in boys to increase adult height.

When looking for the best aromatase inhibitors for men, there are several key points to consider. Firstly, it is important to consider the specific needs of the individual, as different aromatase inhibitors may be more effective for different people. Secondly, it is important to consider the potential side effects of the drug, as some aromatase inhibitors may have more side effects than others. Thirdly, it is important to consider the dosage and frequency of the drug, as this can impact its effectiveness. Fourthly, it is important to consider the cost of the drug, as some aromatase inhibitors may be more expensive than others. Finally, it is important to consult with a healthcare professional before starting any new medication, as they can provide guidance on the best course of action based on an individual’s specific needs and medical history.

In a prior 3-month, double-blind, placebo-controlled study of 37 elderly men with low testosterone levels treated with anastrozole, we demonstrated similar increases in mean testosterone levels to those observed in this study (41). Similar increases in testosterone were also reported in a short-term study in which eugonadal older men were given anastrozole 2 mg daily (42). In that study, Taxel et al. (42) observed changes in BTM with anastrozole therapy; however, the men were eugonadal, received a higher dose of anastrozole, and were not compared with a placebo group. Importantly, in our earlier short-term study (41), we also did not observe any change in BTM, but this study was not long enough to provide meaningful insight regarding the effect of aromatase inhibition on BMD. The hormones estrogen and progesterone are produced by the ovaries in premenopausal women and by some other tissues, including fat and skin, in both premenopausal and postmenopausal women and in men.

Exemestane is a steroidal AI with drug interactions that health-care providers should consider. Exemestane is extensively metabolized by CYP3A4, one of the major enzymes responsible for the metabolism of medications in our body. Any drug that induces the activity of CYP3A4 will decrease levels of exemestane in the body, and the patient could potentially lose some of the Steroids clinical benefit of the drug. Conversely, any medication that inhibits CYP3A4 will prevent the metabolism of exemestane, increasing serum concentrations, which may lead to increased side effects.